The Gremlins In Your Gut

By definition live bacteria - otherwise known as probiotics - are living micro-organisms that can alter your internal micro flora and exert specific health benefits without increasing the risk of antibiotic resistance. 

The human gastrointestinal system is the natural habitat for a large and dynamic bacterial community, which is colonised from birth when we begin to develop a highly complex ecosystem of micro-organisms. 

Babies are born with a sterile intestinal tract but rapidly acquire micro-biota.

Micro-biota refers to the entire community of micro-organisms that colonize the gut; not just bacteria, but also other microbes such as fungi, viruses and protozoans.

These micro-biota have many major functions some of which are still relatively unknown. 

The establishment of the gut microbial population is a rather complex process influenced not just by the mother but also by environmental factors such as hospitalisation, hygienic conditions and antimicrobial procedures. 

It is now believed that these external influences post delivery are more important in gut colonisation than breast-feeding.

The gut flora comprises an amazing 95% of the total number of cells in our bodies (100,000 billion organisms), so it’s not surprising that there’s a lot we still don’t know about what goes on in this vast microbial ecosystem.

What we do know is that the gut micro flora has a profound influence on our health at multiple levels.

It can be affected by a variety of factors including stress, medication, genetics, age and nutrition.  

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Role of a normal gut microbiota


From an immunological perspective, microorganisms are viewed as pathogens by your own immune system, which recognizes and eliminates them. 

However, the majority of bacteria that resides in your gut are non-pathogenic and happily live alongside your own cells in a mutually beneficial relationship. 

Your immune system has evolved to co-exist with the healthy bacteria while it continues to fight of invading pathogens.

immune system bacteria

Functional aspects of the gut microbiota include:

  • Digestive function through enzyme activity. 
  • pH balance of the intestines
  • lactase production
  • Breakdown of bacterial toxins
  • Helps to normalise serum cholesterol and triglycerides

Live bacteria are able to convert cholesterol into a less absorbable form leading to reduced absorption of cholesterol from the gastrointestinal tract therefore a fall in serum cholesterol levels.

  • Mineral absorption
  • Bio transforms plant polysaccharides
  • Stimulates immune function
  • Synthesises vitamins

Bifidobacteria can produce a range of vitamins including folic acid, vitamin B1, B6, B12, and vitamin K, as well as a variety of amino acids. 

  • Releases plant polyphenols
  • Produces short chain fatty acids 
  • Detoxifies many substances
  • Regulates bowel movements
  • Produces natural antimicrobials helping to prevent growth of pathogen

 

Therapeutic Uses


The popularity in the use of live bacteria is growing hugely, largely due to the vast body of scientific evidence supporting it’s health benefits. 

It is well documented that the use of antibiotics disturbs the balance of gut flora and can result in complications such as diarrhoea, gastritis and an overgrowth of Candida.

Candida albicans bacteria

A research review carried out in 2002 revealed that administering live bacteria following antibiotic therapy could reduce the associated diarrhoea and prevent multiplication of Candida albicans. 

In 2010 The American Journal of Gastroenterology reported that administering a blend of lactobacillus acidophilus and lactobacillus casei resulted in a reduced risk of antibiotic associated diarrhoea and clostridium difficile associated diarrhoea. 

An earlier study by Cheng et al in 2005 demonstrated that the use of both lactobacillus acidophilus and bifidobacteria bifidum following antibiotic therapy resulted in a significant reduction of opportunistic pathogen re-growth. 

  
Irritable Bowel Syndrome (IBS) 


IBS is a common complaint where friendly bacteria are thought to exert a beneficial effect. One of the culprits for IBS is thought to be a bacterial overgrowth in the small intestines, so repopulating the gut with healthy bacteria may play a role in alleviating the symptoms. 

Irritable Bowel Syndrome

Promising studies appear to support this theory. In particular one large-scale trial carried out in 2006 assessed the efficacy of Bifidobacterium infantis on women with IBS. Results from this research revealed a significant improvement in abdominal discomfort, wind and incomplete evacuation compared to those in the placebo group. 

 

Inflammatory Bowel disease (IBD)


IBD such as Crohn’s and Ulcerative Colitis may also benefit from the use of friendly bacteria. Research suggests that certain pathogenic bacteria present in the GI tract may aggravate these conditions. Healthy bacteria influences the balance of the gut flora so may be helpful for IBD sufferers. 

Furthermore the yeast Saccharomyces boulardii, has been iidentified as being effective in preventing or shortening the duration of antibiotic-associated diarrhea in Crohn’s patients..


Latest Research


It seems that the gut micro flora may also be implicated in insulin sensitivity and obesity related disorders. Research is now recognising that pre-biotics and friendly bacteria might have beneficial effects on glucose tolerance, post-prandial insulin release and insulin sensitivity. 

A Finnish study carried out in 2009 on 256 pregnant women, identified that the group that undertook nutrition counselling whilst taking Lactobacillus rhamnosus GG & Bifidobacterium lactis Bb12 had better glucose tolerance with higher insulin sensitivity than the placebo group. 

The authors reported that 18% fewer women given the live bacteria had central obesity. They also had an average body fat of 28% compared to 29-30% in the placebo group. 

This study provided evidence of consistently improved glucose metabolism due to combined dietary counselling and live bacteria supplementation.

Exciting new research is also proposing that manipulation of the colonic micro-biota improves chronic fatigue symptoms.

In addition to this a growing body of research is showing the health benefits of taking mixed strains of live bacteria. A study in The Journal of Gastroenterology Hepatology in 2013 found favourable results for using a multi strain probiotic for those with IBS. 

The use of Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus rhamnosus and Streptococcus thermophilus gave substantial relief from symptoms such as pain, discomfort and bloating compared to no change in the placebo group.

This trial also highlighted the need for using live bacteria rather than functional foods such as yogurt drinks, which a previous study had found to be ineffective. 

Investigations within this innovative field have also demonstrated that probiotics offer an advantageous ability to stimulate the immune system and some have even exhibited anti-cancer effects.

Interest in the use of live bacteria within the food industry, from consumers and particularly within the scientific community is growing. It is anticipated that further scientific investigations into this expanding area may uncover even more insights into the beneficial role of friendly bacteria.

 

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Written by: Jacqueline Newson BSc (Hons) Nutritional Therapy


Related Gut Health Stories: 

  1. The Gremlins in Your Gut
  2. IBS: Could the FODMAP Diet Transform Your Life?
  3. Good Health Starts in the Gut
  4. Study: Gluten-Free Diet Influences Gut Health
  5. Your Gut: The Centre of Your Health
  6. Q: Is Your Gut In Balance?
  7. Connections: Leaky Gut and Grains
  8. Highlights: Spotlight on Digestion
  9. Control IBS With These 7 Foods

References

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